| Player | Matches | Goals | Penalties | First match | Last match |
|---|---|---|---|---|---|
| Senkbeil, Kilian | 1 | 0 | 0 | 2017-10-07 | 2017-10-07 |
| Senesie, Sahr | 7 | 1 | 1 | 2003-08-26 | 2004-05-23 |
| Sen, Eren | 3 | 1 | 0 | 2002-08-29 | 2003-02-20 |
| Semic, Lion | 3 | 0 | 0 | 2021-09-03 | 2022-03-29 |
| Selke, Davie | 15 | 14 | 0 | 2013-08-14 | 2014-07-31 |
| Seimen, Dennis | 3 | 0 | 0 | 2023-09-06 | 2024-03-23 |
| Sebastian, Tim | 2 | 0 | 0 | 2003-02-18 | 2003-02-20 |
| Scott, Christopher | 1 | 0 | 0 | 2020-09-03 | 2020-09-03 |
| Schwolow, Alexander | 2 | 0 | 0 | 2010-08-18 | 2011-03-25 |
| Schweinsteiger, Bastian | 7 | 2 | 0 | 2002-08-29 | 2003-05-21 |
| Schwäbe, Marvin | 3 | 0 | 0 | 2013-08-14 | 2013-10-15 |
| Schwaab, Daniel | 7 | 0 | 0 | 2006-09-05 | 2007-07-24 |
| Schutzbach, Maik | 4 | 0 | 0 | 2004-10-21 | 2005-04-13 |
| Schütz, Tom | 5 | 0 | 0 | 2006-11-14 | 2007-04-07 |
| Schürrle, André | 11 | 4 | 0 | 2008-09-04 | 2009-05-26 |
| Schuon, Marcel | 3 | 0 | 0 | 2003-08-26 | 2003-10-18 |
| Schumacher, Till | 4 | 0 | 0 | 2015-11-15 | 2016-03-29 |
| Schulze, Michael | 2 | 0 | 0 | 2008-01-21 | 2008-01-25 |
| Schulze, Kevin | 2 | 0 | 0 | 2010-09-02 | 2010-09-06 |
| Schulz, Philipp | 1 | 0 | 0 | 2024-03-26 | 2024-03-26 |
| Schulz, Nico | 11 | 4 | 0 | 2011-05-31 | 2012-05-30 |
| Schulz, Christian | 4 | 0 | 0 | 2001-09-04 | 2002-03-30 |
| Schuldes, Jamie | 2 | 1 | 0 | 2025-11-15 | 2025-11-18 |
| Schubert, Markus | 7 | 0 | 0 | 2016-09-02 | 2017-03-28 |
| Schrödter, Sascha | 7 | 3 | 1 | 2004-11-24 | 2005-05-18 |
| Schröck, Stephan | 12 | 1 | 0 | 2004-09-15 | 2005-07-26 |
| Schreck, Sam Francis | 6 | 1 | 0 | 2017-08-31 | 2018-03-24 |
| Schorr, Patrick | 2 | 0 | 0 | 2012-11-14 | 2013-03-25 |
| Schorch, Christopher | 3 | 0 | 0 | 2007-09-07 | 2007-09-29 |
| Schönheim, Fabian | 8 | 3 | 0 | 2005-09-12 | 2006-05-30 |
| Schönfelder, Oscar | 8 | 1 | 0 | 2019-09-04 | 2019-11-18 |
| Scholze, Max | 1 | 0 | 0 | 2024-05-22 | 2024-05-22 |
| Schnitzler, Oliver | 10 | 0 | 0 | 2013-11-13 | 2014-07-31 |
| Schnellhardt, Fabian | 8 | 4 | 0 | 2012-09-06 | 2013-06-05 |
| Schneider, Manuel | 3 | 0 | 0 | 2009-09-05 | 2009-10-09 |
| Schmitt, Max | 6 | 0 | 0 | 2024-09-07 | 2025-05-14 |
| Schmiedebach, Manuel | 10 | 1 | 0 | 2006-09-05 | 2007-05-19 |
| Schmidt, Tan-Kenneth | 1 | 0 | 0 | 2020-09-03 | 2020-09-03 |
| Schmidt, Patrick | 1 | 0 | 0 | 2011-08-23 | 2011-08-23 |
| Schmidt, Niklas | 8 | 3 | 2 | 2016-09-02 | 2017-03-25 |
| Schmidt, Dominic | 2 | 1 | 0 | 2019-11-13 | 2019-11-18 |
| Schmidt, Dennis | 6 | 4 | 0 | 2006-10-05 | 2007-07-18 |
| Schmetgens, Mick | 6 | 1 | 0 | 2025-09-06 | 2025-11-18 |
| Schlotterbeck, Nico | 2 | 0 | 0 | 2017-11-12 | 2018-04-25 |
| Schlieck, Timo | 1 | 0 | 0 | 2024-09-10 | 2024-09-10 |
| Schlicke, Ben | 1 | 0 | 0 | 2024-05-22 | 2024-05-22 |
| Schindler, Kevin | 4 | 1 | 0 | 2006-11-14 | 2007-05-19 |
| Schilk, Tobias | 1 | 0 | 0 | 2010-08-18 | 2010-08-18 |
| Scheidhauer, Kevin | 5 | 0 | 0 | 2010-08-18 | 2011-03-29 |
| Schauer, Bennett | 1 | 0 | 0 | 2018-04-25 | 2018-04-25 |